Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome
نویسندگان
چکیده
منابع مشابه
Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome.
The biological effects of high-dose total body ionizing irradiation [(thereafter, irradiation (IR)] are attributed to primary oxidative breakage of biomolecule targets, mitotic, apoptotic and necrotic cell death in the dose-limiting tissues, clastogenic and epigenetic effects, and cascades of functional and reactive responses leading to radiation sickness defined as the acute radiation syndrome...
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Acute radiation syndrome (ARS) or sickness or poisoning or toxicity is induced after a whole body exposure of men to high doses of radiation between 1-12Gy. First symptoms are from the gastrointestinal system, which together with bone marrow are the most sensitive parts of our body. Chronic radiation syndrome (CRS) may be induced by smaller than 1Gy radiation doses or after a mild form of ARS. ...
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Astronauts and cosmonauts are exposed to a wide variety of different hazards while in space that include radiation, which presents one of the most critical barriers to long-term missions. A major deleterious effect directly associated with ionizing radiation is the production of reactive oxygen species (ROS) such as peroxides and hydroxyl radicals. The free radicals generated by ultraviolet (UV...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2019
ISSN: 0449-3060,1349-9157
DOI: 10.1093/jrr/rrz014